Synthesis of a hexahydropyrrolo indole (HPI) compound library.
Bioorg Med Chem
; 23(11): 2636-45, 2015 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-25907365
ABSTRACT
Scaffolds of natural products represent promising starting points for the development of focused compound libraries. Here, we describe the development of a synthetic route to a compound library based on the hexahydropyrrolo indole (HPI) scaffold, the denoting structural motif of the HPI natural product family. To this end, a two-step approach consisting of a batch synthesis of an advanced functionalizable HPI intermediate followed by the establishment of reaction conditions that allow derivatization of this scaffold at three different positions is described. Subsequently, the optimized methods were applied to the synthesis of a 276-member library.
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Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Bibliotecas de Moléculas Pequenas
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Descoberta de Drogas
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Indóis
Idioma:
En
Revista:
Bioorg Med Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Alemanha