Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting.

Hodge, Curtis D; Edwards, Ross A; Markin, Craig J; McDonald, Darin; Pulvino, Mary; Huen, Michael S Y; Zhao, Jiyong; Spyracopoulos, Leo; Hendzel, Michael J; Glover, J N Mark

Hodge, Curtis D; Edwards, Ross A; Markin, Craig J; McDonald, Darin; Pulvino, Mary; Huen, Michael S Y; Zhao, Jiyong; Spyracopoulos, Leo; Hendzel, Michael J; Glover, J N Mark.

Afiliação

Hodge CD; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7.
Edwards RA; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7.
Markin CJ; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7.
McDonald D; Department of Oncology, University of Alberta, Edmonton, Alberta, Canada T6G 1Z2.
Pulvino M; â¥Department of Biomedical Genetics, University of Rochester, Rochester, New York 14642, United States.
Huen MS; §Department of Anatomy and Centre for Cancer Research, The University of Hong Kong, Hong Kong, China.
Zhao J; â¥Department of Biomedical Genetics, University of Rochester, Rochester, New York 14642, United States.
Spyracopoulos L; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7.
Hendzel MJ; Department of Oncology, University of Alberta, Edmonton, Alberta, Canada T6G 1Z2.
Glover JN; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7.

ACS Chem Biol ; 10(7): 1718-28, 2015 Jul 17.

Article em En | MEDLINE | ID: mdl-25909880

Assuntos

Nitrilas/farmacologia; Nitrofuranos/farmacologia; Sulfonas/farmacologia; Enzimas de Conjugação de Ubiquitina/antagonistas & inibidores; Enzimas de Conjugação de Ubiquitina/metabolismo; Ubiquitina/metabolismo; Ubiquitinação/efeitos dos fármacos; Sequência de Aminoácidos; Animais; Linhagem Celular; Humanos; Camundongos; Modelos Moleculares; Dados de Sequência Molecular; Mutação; NF-kappa B/antagonistas & inibidores; Alinhamento de Sequência; Transdução de Sinais/efeitos dos fármacos; Enzimas de Conjugação de Ubiquitina/química; Enzimas de Conjugação de Ubiquitina/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonas / Ubiquitina / Enzimas de Conjugação de Ubiquitina / Ubiquitinação / Nitrilas / Nitrofuranos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: ACS Chem Biol Ano de publicação: 2015 Tipo de documento: Article

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