Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways.

Zhang, Jianbin; Ng, Shukie; Wang, Jigang; Zhou, Jing; Tan, Shi-Hao; Yang, Naidi; Lin, Qingsong; Xia, Dajing; Shen, Han-Ming

Zhang, Jianbin; Ng, Shukie; Wang, Jigang; Zhou, Jing; Tan, Shi-Hao; Yang, Naidi; Lin, Qingsong; Xia, Dajing; Shen, Han-Ming.

Afiliação

Zhang J; a Department of Physiology ; Yong Loo Lin School of Medicine; National University of Singapore ; Singapore.

Autophagy ; 11(4): 629-42, 2015 Apr 03.

Article em En | MEDLINE | ID: mdl-25919885

Assuntos

Apoptose/fisiologia; Autofagia/fisiologia; Fatores de Transcrição Forkhead/metabolismo; Inibidores de Histona Desacetilases/metabolismo; Apoptose/genética; Sobrevivência Celular/fisiologia; Proteína Forkhead Box O1; Humanos; Transdução de Sinais/fisiologia; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

ATG, autophagy-related; BAF, bafilomycin A1; CQ, chloroquine; FOXO, forkhead box O; FOXO1; GFP, green fluorescent protein; MAP1LC3/LC3, microtubule-associated protein 1 light chain 3; MEF, mouse embryonic fibroblast; MTOR; MTOR, mechanistic target of rapamycin; PI3K, phosphoinositide 3-kinase; SAHA, suberoylanilide hydroxamic acid; TSA, trichostatin A; TSC, tuberous sclerosis; autophagy; cancer; cell death; histone deacetylase inhibitors; siRNA, short interfering RNA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Apoptose / Fatores de Transcrição Forkhead / Inibidores de Histona Desacetilases Limite: Humans Idioma: En Revista: Autophagy Ano de publicação: 2015 Tipo de documento: Article

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