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The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-ß1 pathway in human lung fibroblasts.
Schilter, Heidi; Cantemir-Stone, Carmen Z; Leksa, Vladimir; Ohradanova-Repic, Anna; Findlay, Alison D; Deodhar, Mandar; Stockinger, Hannes; Song, Xiaomin; Molloy, Mark; Marsh, Clay B; Jarolimek, Wolfgang.
Afiliação
  • Schilter H; Drug Discovery, Pharmaxis, Australia. Electronic address: heidi.schilter@pharmaxis.com.au.
  • Cantemir-Stone CZ; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, USA.
  • Leksa V; Molecular Immunology Unit, Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria; Institute of Molecular Biology, Slovak Academy of Sciences, Slovak Republic.
  • Ohradanova-Repic A; Molecular Immunology Unit, Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria.
  • Findlay AD; Drug Discovery, Pharmaxis, Australia.
  • Deodhar M; Drug Discovery, Pharmaxis, Australia.
  • Stockinger H; Molecular Immunology Unit, Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria.
  • Song X; Australian Proteome Analysis Facility, Macquarie University, Australia.
  • Molloy M; Australian Proteome Analysis Facility, Macquarie University, Australia.
  • Marsh CB; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, USA.
  • Jarolimek W; Drug Discovery, Pharmaxis, Australia; School of Medical & Molecular Biosciences, University of Technology Sydney, Australia.
Immunol Lett ; 165(2): 90-101, 2015 Jun.
Article em En | MEDLINE | ID: mdl-25929803
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Fibrose Pulmonar Idiopática / Fibroblastos / Organofosfonatos / Pulmão / Manosefosfatos / Manosídeos Limite: Animals / Humans Idioma: En Revista: Immunol Lett Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Fibrose Pulmonar Idiopática / Fibroblastos / Organofosfonatos / Pulmão / Manosefosfatos / Manosídeos Limite: Animals / Humans Idioma: En Revista: Immunol Lett Ano de publicação: 2015 Tipo de documento: Article