Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade.

Taube, Janis M; Young, Geoffrey D; McMiller, Tracee L; Chen, Shuming; Salas, January T; Pritchard, Theresa S; Xu, Haiying; Meeker, Alan K; Fan, Jinshui; Cheadle, Chris; Berger, Alan E; Pardoll, Drew M; Topalian, Suzanne L

Taube, Janis M; Young, Geoffrey D; McMiller, Tracee L; Chen, Shuming; Salas, January T; Pritchard, Theresa S; Xu, Haiying; Meeker, Alan K; Fan, Jinshui; Cheadle, Chris; Berger, Alan E; Pardoll, Drew M; Topalian, Suzanne L.

Afiliação

Taube JM; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins University School of Medicine, B
Young GD; Department of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
McMiller TL; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Chen S; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Salas JT; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Pritchard TS; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Xu H; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Meeker AK; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Fan J; The Lowe Family Genomics Core, Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins University School of Medicine, Baltimore, Maryland.
Cheadle C; The Lowe Family Genomics Core, Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins University School of Medicine, Baltimore, Maryland.
Berger AE; The Lowe Family Genomics Core, Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins University School of Medicine, Baltimore, Maryland.
Pardoll DM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins University School of Medicine, Baltimore, Maryland.
Topalian SL; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland. stopali1@jhmi.edu.

Clin Cancer Res ; 21(17): 3969-76, 2015 Sep 01.

Article em En | MEDLINE | ID: mdl-25944800

Assuntos

Antígeno B7-H1/genética; Regulação Neoplásica da Expressão Gênica; Imunomodulação/genética; Melanoma/genética; Melanoma/imunologia; Antígenos CD/genética; Antígeno B7-H1/metabolismo; Células Cultivadas; Quimiocinas/metabolismo; Citocinas/metabolismo; Perfilação da Expressão Gênica; Humanos; Ligantes; Ativação Linfocitária/imunologia; Linfócitos do Interstício Tumoral/imunologia; Linfócitos do Interstício Tumoral/metabolismo; Melanoma/metabolismo; Melanoma/patologia; Receptor de Morte Celular Programada 1/metabolismo; Transdução de Sinais/efeitos dos fármacos; Microambiente Tumoral/genética; Microambiente Tumoral/imunologia; Proteína do Gene 3 de Ativação de Linfócitos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Imunomodulação / Antígeno B7-H1 / Melanoma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article

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