Increased infection with key periodontal pathogens during gestational diabetes mellitus.
J Clin Periodontol
; 42(6): 506-12, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25959628
ABSTRACT
AIM:
Gestational diabetes mellitus (GDM), gingivitis, infection with specific periodontal pathogens and systemic inflammation each increase the risk for poor pregnancy outcome. We set out to monitor the interactions of gingivitis and GDM with respect to oral infection and the systemic inflammatory burden. MATERIALS ANDMETHODS:
Four case-control groups (n = 117) were recruited, (1) No gingivitis, No GDM (n = 27); (2) Gingivitis, No GDM (n = 31); (3) No gingivitis, GDM (n = 21); and (4) Gingivitis, GDM (n = 38). Oral infection with three key periodontal pathogens was determined by PCR. Systemic inflammation was determined by quantification of CRP by EIA.RESULTS:
Gingivitis during pregnancy was associated with oral infection with Porphyromonas gingivalis, Filifactor alocis and Treponema denticola and combinations thereof (all p < 0.01). GDM was also associated with increased infection with individual and multiple oral pathogens (all p < 0.05). Gingivitis during pregnancy led to a 325% increase in systemic CRP (mean, 2495 versus 8116 ng/ml, p < 0.01).CONCLUSIONS:
Diabetes and gingivitis act in concert to increase risk biomarkers for poor pregnancy outcome.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações Infecciosas na Gravidez
/
Diabetes Gestacional
/
Gengivite
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
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Pregnancy
Idioma:
En
Revista:
J Clin Periodontol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos