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Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates.
Veiseh, Omid; Doloff, Joshua C; Ma, Minglin; Vegas, Arturo J; Tam, Hok Hei; Bader, Andrew R; Li, Jie; Langan, Erin; Wyckoff, Jeffrey; Loo, Whitney S; Jhunjhunwala, Siddharth; Chiu, Alan; Siebert, Sean; Tang, Katherine; Hollister-Lock, Jennifer; Aresta-Dasilva, Stephanie; Bochenek, Matthew; Mendoza-Elias, Joshua; Wang, Yong; Qi, Merigeng; Lavin, Danya M; Chen, Michael; Dholakia, Nimit; Thakrar, Raj; Lacík, Igor; Weir, Gordon C; Oberholzer, Jose; Greiner, Dale L; Langer, Robert; Anderson, Daniel G.
Afiliação
  • Veiseh O; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [3] Depar
  • Doloff JC; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
  • Ma M; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA [3] Section on Islet Cell and Regene
  • Vegas AJ; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
  • Tam HH; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
  • Bader AR; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
  • Li J; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
  • Langan E; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
  • Wyckoff J; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA.
  • Loo WS; Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
  • Jhunjhunwala S; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
  • Chiu A; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
  • Siebert S; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
  • Tang K; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
  • Hollister-Lock J; Section on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA.
  • Aresta-Dasilva S; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
  • Bochenek M; Division of Transplantation, Department of Surgery, University of Illinois at Chicago, 840 South Wood Street, Chicago, Illinois 60612, USA.
  • Mendoza-Elias J; Division of Transplantation, Department of Surgery, University of Illinois at Chicago, 840 South Wood Street, Chicago, Illinois 60612, USA.
  • Wang Y; Division of Transplantation, Department of Surgery, University of Illinois at Chicago, 840 South Wood Street, Chicago, Illinois 60612, USA.
  • Qi M; Division of Transplantation, Department of Surgery, University of Illinois at Chicago, 840 South Wood Street, Chicago, Illinois 60612, USA.
  • Lavin DM; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
  • Chen M; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
  • Dholakia N; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
  • Thakrar R; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
  • Lacík I; Department for Biomaterials Research, Polymer Institute of the Slovak Academy of Sciences, Dubravska cesta 9, 845 41 Bratislava, Slovakia.
  • Weir GC; Section on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA.
  • Oberholzer J; Division of Transplantation, Department of Surgery, University of Illinois at Chicago, 840 South Wood Street, Chicago, Illinois 60612, USA.
  • Greiner DL; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
  • Langer R; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [3] Depar
  • Anderson DG; 1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [3] Depar
Nat Mater ; 14(6): 643-51, 2015 Jun.
Article em En | MEDLINE | ID: mdl-25985456
ABSTRACT
The efficacy of implanted biomedical devices is often compromised by host recognition and subsequent foreign body responses. Here, we demonstrate the role of the geometry of implanted materials on their biocompatibility in vivo. In rodent and non-human primate animal models, implanted spheres 1.5 mm and above in diameter across a broad spectrum of materials, including hydrogels, ceramics, metals and plastics, significantly abrogated foreign body reactions and fibrosis when compared with smaller spheres. We also show that for encapsulated rat pancreatic islet cells transplanted into streptozotocin-treated diabetic C57BL/6 mice, islets prepared in 1.5-mm alginate capsules were able to restore blood-glucose control for up to 180 days, a period more than five times longer than for transplanted grafts encapsulated within conventionally sized 0.5-mm alginate capsules. Our findings suggest that the in vivo biocompatibility of biomedical devices can be significantly improved simply by tuning their spherical dimensions.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Reação a Corpo Estranho Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nat Mater Assunto da revista: CIENCIA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Reação a Corpo Estranho Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nat Mater Assunto da revista: CIENCIA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article