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Combinations of ß-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection.
Rullas, Joaquín; Dhar, Neeraj; McKinney, John D; García-Pérez, Adolfo; Lelievre, Joël; Diacon, Andreas H; Hugonnet, Jean-Emmanuel; Arthur, Michel; Angulo-Barturen, Iñigo; Barros-Aguirre, David; Ballell, Lluís.
Afiliação
  • Rullas J; Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain Open Collaborative Model for Tuberculosis Lead Optimisation (ORCHID) Consortium‡
  • Dhar N; School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL), Lausanne, Switzerland Open Collaborative Model for Tuberculosis Lead Optimisation (ORCHID) Consortium‡
  • McKinney JD; School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL), Lausanne, Switzerland Open Collaborative Model for Tuberculosis Lead Optimisation (ORCHID) Consortium‡
  • García-Pérez A; Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain Open Collaborative Model for Tuberculosis Lead Optimisation (ORCHID) Consortium‡
  • Lelievre J; Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain Open Collaborative Model for Tuberculosis Lead Optimisation (ORCHID) Consortium‡
  • Diacon AH; Open Collaborative Model for Tuberculosis Lead Optimisation (ORCHID) Consortium‡ Department of Medical Biochemistry, Stellenbosch University, Tygerberg, South Africa.
  • Hugonnet JE; Centre de Recherche des Cordeliers, LRMA, Equipe 12, Université Pierre et Marie Curie-Paris 6, UMR S 872, Paris, France Institut National de la Santé et de la Recherche Médicale (INSERM), U872, Paris, France Université Paris Descartes, Sorbonne Paris Cité, UMR S 872, Paris, France Open Collaborative
  • Arthur M; Centre de Recherche des Cordeliers, LRMA, Equipe 12, Université Pierre et Marie Curie-Paris 6, UMR S 872, Paris, France Institut National de la Santé et de la Recherche Médicale (INSERM), U872, Paris, France Université Paris Descartes, Sorbonne Paris Cité, UMR S 872, Paris, France Open Collaborative
  • Angulo-Barturen I; Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain Open Collaborative Model for Tuberculosis Lead Optimisation (ORCHID) Consortium‡
  • Barros-Aguirre D; Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain Open Collaborative Model for Tuberculosis Lead Optimisation (ORCHID) Consortium‡
  • Ballell L; Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain Open Collaborative Model for Tuberculosis Lead Optimisation (ORCHID) Consortium‡ lluis.p.ballell@gsk.com.
Antimicrob Agents Chemother ; 59(8): 4997-9, 2015 Aug.
Article em En | MEDLINE | ID: mdl-25987618
ABSTRACT
We report here a dehydropeptidase-deficient murine model of tuberculosis (TB) infection that is able to partially uncover the efficacy of marketed broad-spectrum ß-lactam antibiotics alone and in combination. Reductions of up to 2 log CFU in the lungs of TB-infected mice after 8 days of treatment compared to untreated controls were obtained at blood drug concentrations and time above the MIC (T>MIC) below clinically achievable levels in humans. These findings provide evidence supporting the potential of ß-lactams as safe and mycobactericidal components of new combination regimens against TB with or without resistance to currently used drugs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Respiratórias / Tuberculose / Beta-Lactamas / Dipeptidases / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Respiratórias / Tuberculose / Beta-Lactamas / Dipeptidases / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2015 Tipo de documento: Article