From ATP to PTP and Back: A Dual Function for the Mitochondrial ATP Synthase.
Circ Res
; 116(11): 1850-62, 2015 May 22.
Article
em En
| MEDLINE
| ID: mdl-25999424
ABSTRACT
Mitochondria not only play a fundamental role in heart physiology but are also key effectors of dysfunction and death. This dual role assumes a new meaning after recent advances on the nature and regulation of the permeability transition pore, an inner membrane channel whose opening requires matrix Ca(2+) and is modulated by many effectors including reactive oxygen species, matrix cyclophilin D, Pi (inorganic phosphate), and matrix pH. The recent demonstration that the F-ATP synthase can reversibly undergo a Ca(2+)-dependent transition to form a channel that mediates the permeability transition opens new perspectives to the field. These findings demand a reassessment of the modifications of F-ATP synthase that take place in the heart under pathological conditions and of their potential role in determining the transition of F-ATP synthase from and energy-conserving into an energy-dissipating device.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trifosfato de Adenosina
/
Cálcio
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ATPases Mitocondriais Próton-Translocadoras
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Proteínas de Transporte da Membrana Mitocondrial
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Mitocôndrias Cardíacas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Circ Res
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Itália