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Distribution of elastin and collagen in canine lung alveolar parenchyma.
Oldmixon, E H; Hoppin, F G.
Afiliação
  • Oldmixon EH; Department of Medicine, Brown University, Pawtucket, Rhode Island 02860.
J Appl Physiol (1985) ; 67(5): 1941-9, 1989 Nov.
Article em En | MEDLINE | ID: mdl-2600027
We have quantified the fibrous collagen (predominantly type I) and elastin in four locations of perceived mechanical importance: one quasi-planar feature, the alveolar septum or wall (W), and three linear features, the junction (J) of three septa, the free edges (E) of septa, and the line along which two septa join at a distinct angle or bend (B). The frequencies of these four features on light micrographs and the areas of transections through collagen and elastin seen on electron micrographs were combined to give the volumes of collagen and elastin within each feature. We find that E and B have similar compositions and contain most (4/5) of the parenchymal elastin in their relatively heavy cables. The E and B are interconnected and similar in location and composition, and they may constitute a functional entity in which elastin provides tension over a range of lung volumes, opposing septal tensions. In J and W, elastin is typically sparse and fine. Calculations, however, suggest it contributes the dominant portion of septal tension at lower lung volumes. Elastin may be essential to stabilizing septal configuration. Collagen, on the other hand, is distributed relatively evenly throughout E, B, J, and W, consistent with the role of protecting all components against rupture.
Assuntos
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Base de dados: MEDLINE Assunto principal: Alvéolos Pulmonares / Colágeno / Elastina Limite: Animals Idioma: En Revista: J Appl Physiol (1985) Assunto da revista: FISIOLOGIA Ano de publicação: 1989 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Alvéolos Pulmonares / Colágeno / Elastina Limite: Animals Idioma: En Revista: J Appl Physiol (1985) Assunto da revista: FISIOLOGIA Ano de publicação: 1989 Tipo de documento: Article