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Ligand-Enabled Stereoselective ß-C(sp(3))-H Fluorination: Synthesis of Unnatural Enantiopure anti-ß-Fluoro-α-amino Acids.
Zhu, Ru-Yi; Tanaka, Keita; Li, Gen-Cheng; He, Jian; Fu, Hai-Yan; Li, Su-Hua; Yu, Jin-Quan.
Afiliação
  • Zhu RY; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Tanaka K; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Li GC; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • He J; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Fu HY; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Li SH; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Yu JQ; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
J Am Chem Soc ; 137(22): 7067-70, 2015 Jun 10.
Article em En | MEDLINE | ID: mdl-26001406
ABSTRACT
A quinoline-based ligand was shown to promote palladium-catalyzed ß-C(sp(3))-H fluorination for the first time. A range of unnatural enantiopure fluorinated α-amino acids were obtained through sequential ß-C(sp(3))-H arylation and subsequent stereoselective fluorination from readily available L-alanine.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Flúor / Aminoácidos Idioma: En Revista: J Am Chem Soc Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Flúor / Aminoácidos Idioma: En Revista: J Am Chem Soc Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos