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Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates.
Shen, Xiaoying; Duffy, Ryan; Howington, Robert; Cope, Alethea; Sadagopal, Shanmugalakshmi; Park, Haesun; Pal, Ranajit; Kwa, Suefen; Ding, Song; Yang, Otto O; Fouda, Genevieve G; Le Grand, Roger; Bolton, Diane; Esteban, Mariano; Phogat, Sanjay; Roederer, Mario; Amara, Rama R; Picker, Louis J; Seder, Robert A; McElrath, M Juliana; Barnett, Susan; Permar, Sallie R; Shattock, Robin; DeVico, Anthony L; Felber, Barbara K; Pavlakis, George N; Pantaleo, Giuseppe; Korber, Bette T; Montefiori, David C; Tomaras, Georgia D.
Afiliação
  • Shen X; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA sxshen@duke.edu gdt@duke.edu.
  • Duffy R; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
  • Howington R; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
  • Cope A; Mucosal Infection & Immunity Group, Section of Infectious Diseases, Imperial College London, London, United Kingdom.
  • Sadagopal S; Department of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
  • Park H; Vaccine & Gene Therapy Institute (VGTI), Oregon Health & Science University, Portland, Oregon, USA.
  • Pal R; Advanced Bioscience Laboratories Inc., Rockville, Maryland, USA.
  • Kwa S; Department of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
  • Ding S; Laboratory of AIDS Immunopathogenesis, Service of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
  • Yang OO; Department of Medicine, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA AIDS Healthcare Foundation, Los Angeles, Californ
  • Fouda GG; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
  • Le Grand R; CEA, Division of Immuno-Virology-IMDIT Center, DSV, iMETI, Fontenay-aux-Roses, Inserm-U1184, Université Paris-Sud, Orsay, France.
  • Bolton D; Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA.
  • Esteban M; Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
  • Phogat S; Sanofi Pasteur, Swiftwater, PA, USA.
  • Roederer M; Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA.
  • Amara RR; Department of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
  • Picker LJ; Vaccine & Gene Therapy Institute (VGTI), Oregon Health & Science University, Portland, Oregon, USA.
  • Seder RA; Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA.
  • McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Barnett S; Novartis Vaccines and Diagnostics, Inc., Cambridge, Massachusetts, USA.
  • Permar SR; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
  • Shattock R; Mucosal Infection & Immunity Group, Section of Infectious Diseases, Imperial College London, London, United Kingdom.
  • DeVico AL; Institute for Human Virology, Baltimore, Maryland, USA.
  • Felber BK; Human Retrovirus Pathogenesis Section, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.
  • Pavlakis GN; Human Retrovirus Section, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.
  • Pantaleo G; Laboratory of AIDS Immunopathogenesis, Service of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
  • Korber BT; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Álamos, New Mexico, USA.
  • Montefiori DC; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
  • Tomaras GD; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA Department of
J Virol ; 89(16): 8643-50, 2015 Aug.
Article em En | MEDLINE | ID: mdl-26018159
To evaluate antibody specificities induced by simian immunodeficiency virus (SIV) versus human immunodeficiency virus type 1 (HIV-1) envelope antigens in nonhuman primate (NHP), we profiled binding antibody responses to linear epitopes in NHP studies with HIV-1 or SIV immunogens. We found that, overall, HIV-1 Env IgG responses were dominated by V3, with the notable exception of the responses to the vaccine strain A244 Env that were dominated by V2, whereas the anti-SIVmac239 Env responses were dominated by V2 regardless of the vaccine regimen.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Primatas / Proteínas do Envelope Viral / HIV-1 / Vírus da Imunodeficiência Símia / Anticorpos Antivirais / Epitopos Limite: Animals Idioma: En Revista: J Virol Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Primatas / Proteínas do Envelope Viral / HIV-1 / Vírus da Imunodeficiência Símia / Anticorpos Antivirais / Epitopos Limite: Animals Idioma: En Revista: J Virol Ano de publicação: 2015 Tipo de documento: Article