Silica-based 2-(N,N-dimethylamino)-1,3-propanediol hydrophilic interaction liquid chromatography stationary phase for separating cephalosporins and carbapenems.
Anal Bioanal Chem
; 407(20): 6217-20, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26022095
ABSTRACT
A silica-based stationary phase bearing both hydrophilic hydroxyl and amino groups was developed by covalently bonding a small molecular N,N-dimethylamino 1,3-propanediol moiety onto silica beads via copper(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition (CuAAC). This new stationary phase showed good HILIC characteristics and high column efficiency (the theoretical plate number is up to 37000 plates m(-1) in the case of inosine) in the separation of polar compounds, such as nucleosides and bases, organic acids, cephalosporins, and carbapenems.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Propilenoglicóis
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Carbapenêmicos
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Cefalosporinas
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Cromatografia Líquida de Alta Pressão
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Dióxido de Silício
Idioma:
En
Revista:
Anal Bioanal Chem
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
China