Gestational weight gain and the risk of offspring obesity at 10 and 16 years: a prospective cohort study in low-income women.
BJOG
; 122(10): 1395-402, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-26032698
ABSTRACT
OBJECTIVE:
To study the association between gestational weight gain (GWG) and offspring obesity risk at ages chosen to approximate prepuberty (10 years) and postpuberty (16 years).DESIGN:
Prospective pregnancy cohort.SETTING:
Pittsburgh, PA, USA. SAMPLE Low-income pregnant women (n = 514) receiving prenatal care at an obstetric residency clinic and their singleton offspring.METHODS:
Gestational weight gain was classified based on maternal GWG-for-gestational-age Z-score charts and was modelled using flexible spline terms in modified multivariable Poisson regression models. MAIN OUTCOMEMEASURES:
Obesity at 10 or 16 years, defined as body mass index (BMI) Z-scores ≥95th centile of the 2000 CDC references, based on measured height and weight.RESULTS:
The prevalence of offspring obesity was 20% at 10 years and 22% at 16 years. In the overall sample, the risk of offspring obesity at 10 and 16 years increased when GWG exceeded a GWG Z-score of 0 SD (equivalent to 30 kg at 40 weeks); but for gains below a Z-score of 0 SD there was no relationship with child obesity risk. The association between GWG and offspring obesity varied by prepregnancy BMI. Among mothers with a pregravid BMI <25 kg/m(2) , the risk of offspring obesity increased when GWG Z-score exceeded 0 SD, yet among overweight women (BMI ≥25 kg/m(2) ), there was no association between GWG Z-scores and offspring obesity risk.CONCLUSIONS:
Among lean women, higher GWG may have lasting effects on offspring obesity risk.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
/
Aumento de Peso
/
Obesidade Infantil
Tipo de estudo:
Etiology_studies
/
Observational_studies
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Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Female
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Humans
/
Male
/
Pregnancy
País/Região como assunto:
America do norte
Idioma:
En
Revista:
BJOG
Assunto da revista:
GINECOLOGIA
/
OBSTETRICIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos