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Myotonic dystrophy health index: Correlations with clinical tests and patient function.
Heatwole, Chad; Bode, Rita; Johnson, Nicholas E; Dekdebrun, Jeanne; Dilek, Nuran; Eichinger, Katy; Hilbert, James E; Logigian, Eric; Luebbe, Elizabeth; Martens, William; Mcdermott, Michael P; Pandya, Shree; Puwanant, Araya; Rothrock, Nan; Thornton, Charles; Vickrey, Barbara G; Victorson, David; Moxley, Richard T.
Afiliação
  • Heatwole C; The University of Rochester Medical Center, Department of Neurology, 601 Elmwood Avenue, Box 673, Rochester, New York, 14642, USA.
  • Bode R; Psychometric Consultant, Chicago, Illinois, USA.
  • Johnson NE; The University of Utah, Salt Lake City, Utah, USA.
  • Dekdebrun J; The University of Rochester Medical Center, Department of Neurology, 601 Elmwood Avenue, Box 673, Rochester, New York, 14642, USA.
  • Dilek N; The University of Rochester Medical Center, Department of Neurology, 601 Elmwood Avenue, Box 673, Rochester, New York, 14642, USA.
  • Eichinger K; The University of Rochester Medical Center, Department of Neurology, 601 Elmwood Avenue, Box 673, Rochester, New York, 14642, USA.
  • Hilbert JE; The University of Rochester Medical Center, Department of Neurology, 601 Elmwood Avenue, Box 673, Rochester, New York, 14642, USA.
  • Logigian E; The University of Rochester Medical Center, Department of Neurology, 601 Elmwood Avenue, Box 673, Rochester, New York, 14642, USA.
  • Luebbe E; The University of Rochester Medical Center, Department of Neurology, 601 Elmwood Avenue, Box 673, Rochester, New York, 14642, USA.
  • Martens W; The University of Rochester Medical Center, Department of Neurology, 601 Elmwood Avenue, Box 673, Rochester, New York, 14642, USA.
  • Mcdermott MP; The University of Rochester Medical Center, Department of Neurology, 601 Elmwood Avenue, Box 673, Rochester, New York, 14642, USA.
  • Pandya S; The University of Rochester Medical Center, Department of Biostatistics and Computational Biology, Rochester, New York, USA.
  • Puwanant A; The University of Rochester Medical Center, Department of Neurology, 601 Elmwood Avenue, Box 673, Rochester, New York, 14642, USA.
  • Rothrock N; The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Thornton C; Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Vickrey BG; The University of Rochester Medical Center, Department of Neurology, 601 Elmwood Avenue, Box 673, Rochester, New York, 14642, USA.
  • Victorson D; David Geffen School of Medicine, UCLA Medical Center, Los Angeles, California, USA.
  • Moxley RT; Greater Los Angeles VA HealthCare System, Los Angeles, California, USA.
Muscle Nerve ; 53(2): 183-90, 2016 Feb.
Article em En | MEDLINE | ID: mdl-26044513
ABSTRACT

INTRODUCTION:

The Myotonic Dystrophy Health Index (MDHI) is a disease-specific patient-reported outcome measure. Here, we examine the associations between the MDHI and other measures of disease burden in a cohort of individuals with myotonic dystrophy type-1 (DM1).

METHODS:

We conducted a cross-sectional study of 70 patients with DM1. We examined the associations between MDHI total and subscale scores and scores from other clinical tests. Participants completed assessments of strength, myotonia, motor and respiratory function, ambulation, and body composition. Participants also provided blood samples, underwent physician evaluations, and completed other patient-reported outcome measures.

RESULTS:

MDHI total and subscale scores were strongly associated with muscle strength, myotonia, motor function, and other clinical measures.

CONCLUSIONS:

Patient-reported health status, as measured by the MDHI, is associated with alternative measures of clinical health. These results support the use of the MDHI as a valid tool to measure disease burden in DM1 patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Índice de Gravidade de Doença / Avaliação de Resultados em Cuidados de Saúde / Distrofia Miotônica Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Muscle Nerve Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Índice de Gravidade de Doença / Avaliação de Resultados em Cuidados de Saúde / Distrofia Miotônica Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Muscle Nerve Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos