Myotonic dystrophy health index: Correlations with clinical tests and patient function.
Muscle Nerve
; 53(2): 183-90, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26044513
ABSTRACT
INTRODUCTION:
The Myotonic Dystrophy Health Index (MDHI) is a disease-specific patient-reported outcome measure. Here, we examine the associations between the MDHI and other measures of disease burden in a cohort of individuals with myotonic dystrophy type-1 (DM1).METHODS:
We conducted a cross-sectional study of 70 patients with DM1. We examined the associations between MDHI total and subscale scores and scores from other clinical tests. Participants completed assessments of strength, myotonia, motor and respiratory function, ambulation, and body composition. Participants also provided blood samples, underwent physician evaluations, and completed other patient-reported outcome measures.RESULTS:
MDHI total and subscale scores were strongly associated with muscle strength, myotonia, motor function, and other clinical measures.CONCLUSIONS:
Patient-reported health status, as measured by the MDHI, is associated with alternative measures of clinical health. These results support the use of the MDHI as a valid tool to measure disease burden in DM1 patients.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Índice de Gravidade de Doença
/
Avaliação de Resultados em Cuidados de Saúde
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Distrofia Miotônica
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Muscle Nerve
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos