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I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3ß signaling pathway.
Ohta, Etsuro; Nihira, Tomoko; Uchino, Akiko; Imaizumi, Yoichi; Okada, Yohei; Akamatsu, Wado; Takahashi, Kayoko; Hayakawa, Hideki; Nagai, Makiko; Ohyama, Manabu; Ryo, Masafuchi; Ogino, Mieko; Murayama, Shigeo; Takashima, Akihiko; Nishiyama, Kazutoshi; Mizuno, Yoshikuni; Mochizuki, Hideki; Obata, Fumiya; Okano, Hideyuki.
Afiliação
  • Ohta E; R & D Center for Cell Design, Institute for Regenerative Medicine and Cell Design, Kitasato University School of Allied Health Sciences, Kanagawa, Japan, Division of Clinical Immunology, Graduate School of Medical Sciences, Department of Physiology.
  • Nihira T; Department of Neuro-Regenerative Medicine, Department of Physiology.
  • Uchino A; Department of Neurology, Graduate School of Medical Sciences, Kitasato University, Kanagawa, Japan, Department of the Brain Bank for Aging Research.
  • Imaizumi Y; Department of Physiology.
  • Okada Y; Department of Physiology, Department of Neurology, Aichi Medical University School of Medicine, Aichi, Japan.
  • Akamatsu W; Department of Physiology, Center for Genomic and Regenerative Medicine, Juntendo University School of Medicine, Tokyo, Japan.
  • Takahashi K; Department of Medical Laboratory, Kitasato University Hospital, Kanagawa, Japan.
  • Hayakawa H; Department of Neuro-Regenerative Medicine.
  • Nagai M; Department of Neurology, Kitasato University School of Medicine, Kanagawa, Japan.
  • Ohyama M; Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
  • Ryo M; Department of Neurology, Kitasato University School of Medicine, Kanagawa, Japan.
  • Ogino M; Department of Neurology, Kitasato University School of Medicine, Kanagawa, Japan.
  • Murayama S; Department of the Brain Bank for Aging Research, Department of Neurology, Department of Bioresource Center (the Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
  • Takashima A; Department of Neurobiology, National Center for Geriatrics and Gerontology, Obu, Japan and.
  • Nishiyama K; Department of Neurology, Graduate School of Medical Sciences, Kitasato University, Kanagawa, Japan, Department of Neurology, Kitasato University School of Medicine, Kanagawa, Japan.
  • Mizuno Y; Department of Neuro-Regenerative Medicine.
  • Mochizuki H; Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Obata F; R & D Center for Cell Design, Institute for Regenerative Medicine and Cell Design, Kitasato University School of Allied Health Sciences, Kanagawa, Japan, Division of Clinical Immunology, Graduate School of Medical Sciences.
  • Okano H; Department of Physiology, hidokano@a2.keio.jp.
Hum Mol Genet ; 24(17): 4879-900, 2015 Sep 01.
Article em En | MEDLINE | ID: mdl-26056228
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteínas tau / Proteínas Serina-Treonina Quinases / Quinase 3 da Glicogênio Sintase / Proteínas Proto-Oncogênicas c-akt / Células-Tronco Pluripotentes Induzidas / Mutação / Neurônios Limite: Animals / Humans Idioma: En Revista: Hum Mol Genet Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteínas tau / Proteínas Serina-Treonina Quinases / Quinase 3 da Glicogênio Sintase / Proteínas Proto-Oncogênicas c-akt / Células-Tronco Pluripotentes Induzidas / Mutação / Neurônios Limite: Animals / Humans Idioma: En Revista: Hum Mol Genet Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2015 Tipo de documento: Article