Proteomics dedicated to biofilmology: What have we learned from a decade of research?
Med Microbiol Immunol
; 205(1): 1-19, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26068406
ABSTRACT
Advances in proteomics techniques over the past decade, closely integrated with genomic and physicochemical approach, have played a great role in developing knowledge of the biofilm lifestyle of bacteria. Despite bacterial proteome versatility, many studies have demonstrated the ability of proteomics approaches to elucidating the biofilm phenotype. Though these investigations have been largely used for biofilm studies in the last decades, they represent, however, a very low percentage of proteomics works performed up to now. Such approaches have offered new targets for combating microbial biofilms by providing a comprehensive quantitative and qualitative overview of their protein cell content. Herein, we summarized the state of the art in knowledge about biofilm physiology after one decade of proteomic analysis. In a second part, we highlighted missing research tracks for the next decade, emphasizing the emergence of posttranslational modifications in proteomic studies stemming from recent advances in mass spectrometry-based proteomics.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biofilmes
/
Proteoma
/
Proteômica
Tipo de estudo:
Qualitative_research
Limite:
Humans
Idioma:
En
Revista:
Med Microbiol Immunol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
França