Metabolism of the anthelmintic drug niclosamide by cytochrome P450 enzymes and UDP-glucuronosyltransferases: metabolite elucidation and main contributions from CYP1A2 and UGT1A1.

Lu, Danyi; Ma, Zhiguo; Zhang, Tianpeng; Zhang, Xingwang; Wu, Baojian

Lu, Danyi; Ma, Zhiguo; Zhang, Tianpeng; Zhang, Xingwang; Wu, Baojian.

Afiliação

Lu D; a Division of Pharmaceutics , College of Pharmacy, Jinan University , Guangzhou , P.R. China.
Ma Z; a Division of Pharmaceutics , College of Pharmacy, Jinan University , Guangzhou , P.R. China.
Zhang T; a Division of Pharmaceutics , College of Pharmacy, Jinan University , Guangzhou , P.R. China.
Zhang X; a Division of Pharmaceutics , College of Pharmacy, Jinan University , Guangzhou , P.R. China.
Wu B; a Division of Pharmaceutics , College of Pharmacy, Jinan University , Guangzhou , P.R. China.

Xenobiotica ; 46(1): 1-13, 2016.

Article em En | MEDLINE | ID: mdl-26068521

Assuntos

Anti-Helmínticos/metabolismo; Citocromo P-450 CYP1A2/metabolismo; Glucuronosiltransferase/metabolismo; Metaboloma; Niclosamida/metabolismo; Animais; Glucuronídeos/metabolismo; Hidroxilação; Cinética; Microssomos Hepáticos/metabolismo

Palavras-chave

CYP; UGT; glucuronidation; hydroxylation; niclosamide; reaction phenotyping

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glucuronosiltransferase / Citocromo P-450 CYP1A2 / Metaboloma / Anti-Helmínticos / Niclosamida Limite: Animals Idioma: En Revista: Xenobiotica Ano de publicação: 2016 Tipo de documento: Article

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