Synthesis of biscoumarin and dihydropyran derivatives as two novel classes of potential anti-bacterial derivatives.
Arch Pharm Res
; 39(10): 1349-1355, 2016 Oct.
Article
em En
| MEDLINE
| ID: mdl-26077886
ABSTRACT
A series of bisoumarin (1-4) and dihydropyran (5-8) derivatives were successfully synthesized as new antibacterial agents. The molecular structures of three representative compounds 1, 5 and 7 were confirmed by single crystal X-ray diffraction study. Among these compounds tested toward Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), and USA 300 (Los Angeles County clone, LAC), compounds 1 and 2 displayed the most potent antibacterial activity. Additionally, the HB energy in biscoumarins 1-4 was calculated by density functional theory (DFT) [B3LYP/6-31G*] method.
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Base de dados:
MEDLINE
Assunto principal:
Cumarínicos
/
Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
Arch Pharm Res
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
China