Hepatitis B Virus Reactivation During Successful Treatment of Hepatitis C Virus With Sofosbuvir and Simeprevir.

Collins, Jeffrey M; Raphael, Kara Loren; Terry, Charles; Cartwright, Emily J; Pillai, Anjana; Anania, Frank A; Farley, Monica M

Collins, Jeffrey M; Raphael, Kara Loren; Terry, Charles; Cartwright, Emily J; Pillai, Anjana; Anania, Frank A; Farley, Monica M.

Afiliação

Collins JM; Division of Infectious Diseases, Department of Medicine.
Raphael KL; Department of Medicine.
Terry C; Department of Medicine.
Cartwright EJ; Division of Infectious Diseases, Department of Medicine Atlanta Veterans Affairs Medical Center, Georgia.
Pillai A; Division of Digestive Diseases, Department of Medicine Emory Transplant Center, Emory University School of Medicine.
Anania FA; Division of Digestive Diseases, Department of Medicine Atlanta Veterans Affairs Medical Center, Georgia.
Farley MM; Division of Infectious Diseases, Department of Medicine Atlanta Veterans Affairs Medical Center, Georgia.

Clin Infect Dis ; 61(8): 1304-6, 2015 Oct 15.

Article em En | MEDLINE | ID: mdl-26082511

ABSTRACT

ABSTRACT

Treatment of hepatitis C virus with potent, interferon-free, direct-acting antiviral regimens with no activity against hepatitis B virus (HBV) may increase the risk for HBV reactivation in coinfected patients. We present 2 cases of HBV reactivation during treatment with an all-oral regimen of simeprevir and sofosbuvir and discuss strategies to prevent HBV flare.

Assuntos

Antivirais/uso terapêutico; Coinfecção; Vírus da Hepatite B/fisiologia; Hepatite B/complicações; Hepatite C Crônica/complicações; Hepatite C Crônica/tratamento farmacológico; Simeprevir/uso terapêutico; Sofosbuvir/uso terapêutico; Administração Oral; Antivirais/administração & dosagem; Quimioterapia Combinada; Hepatite B/virologia; Hepatite C Crônica/virologia; Humanos; Masculino; Pessoa de Meia-Idade; Fatores de Risco; Simeprevir/administração & dosagem; Sofosbuvir/administração & dosagem

Palavras-chave

HBV reactivation; HBV/HCV coinfection; acute hepatitis; simeprevir; sofosbuvir

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Vírus da Hepatite B / Hepatite C Crônica / Coinfecção / Simeprevir / Sofosbuvir / Hepatite B Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans / Male / Middle aged Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2015 Tipo de documento: Article

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