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Actinobenzoquinoline and Actinophenanthrolines A-C, Unprecedented Alkaloids from a Marine Actinobacterium.
Nam, Sang-Jip; Kauffman, Christopher A; Jensen, Paul R; Moore, Curtis E; Rheingold, Arnold L; Fenical, William.
Afiliação
  • Nam SJ; †Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, and ‡Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0204, United States.
  • Kauffman CA; †Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, and ‡Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0204, United States.
  • Jensen PR; †Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, and ‡Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0204, United States.
  • Moore CE; †Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, and ‡Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0204, United States.
  • Rheingold AL; †Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, and ‡Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0204, United States.
  • Fenical W; †Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, and ‡Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0204, United States.
Org Lett ; 17(13): 3240-3, 2015 Jul 02.
Article em En | MEDLINE | ID: mdl-26084575
ABSTRACT
Chemical investigation of a marine actinomycete within the family Streptomycetaceae (our strain CNQ-149) has led to the isolation of the unprecedented alkaloids, actinobenzoquinoline (1) and actinophenanthrolines A-C (2-4). The chemical structures of 1-4 were assigned by interpretation of NMR spectroscopic data, and their absolute configurations were assigned by X-ray analysis. Actinobenzoquinoline possesses a 5-methyloxazolidin-4-one moiety and a dihydrobenzo[h]quinoline core structure, while actinophenanthrolines A-C are composed of hydroxypropanamide-substituted 1,7-phenanthroline core skeletons.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenantrolinas / Quinolinas / Actinobacteria / Alcaloides Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenantrolinas / Quinolinas / Actinobacteria / Alcaloides Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos