Palladium-Catalyzed Carbonylation of (Hetero)Aryl, Alkenyl and Allyl Halides by Means of N-Hydroxysuccinimidyl Formate as CO Surrogate.
J Org Chem
; 80(13): 6537-44, 2015 Jul 02.
Article
em En
| MEDLINE
| ID: mdl-26098725
ABSTRACT
An efficient Pd-catalyzed carbonylation protocol is described for the coupling of a large panel of aryl, heteroaryl, benzyl, vinyl and allyl halides 2 with the unusual N-hydroxysuccinimidyl (NHS) formate 1 as a CO surrogate to afford the corresponding valuable NHS esters 3. High conversion to the coupling products was achieved with up to 98% yield by means of Pd(OAc)2/Xantphos catalyst system.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Monóxido de Carbono
/
Alcenos
/
Formiatos
/
Hidrocarbonetos Halogenados
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
França