Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess.
Sci Rep
; 5: 11496, 2015 Jun 23.
Article
em En
| MEDLINE
| ID: mdl-26099471
ABSTRACT
Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory infertility, metabolic syndrome and type 2 diabetes. The metabolic derangements that determine these long-term health risks remain to be clarified. Here we use NMR and MS-based metabolomics to show that serum levels of methionine sulfoxide in HIAE girls are an indicator of the degree of oxidation of methionine-148 residue in apolipoprotein-A1. Oxidation of apo-A1 in methionine-148, in turn, leads to an impaired maturation of high-density lipoproteins (HDL) that is reflected in a decline of large HDL particles. Notably, such metabolic alterations occur in the absence of impaired glucose tolerance, hyperglycemia and hypertriglyceridemia, and were partially restored after 18 months of treatment with a low-dose combination of pioglitazone, metformin and flutamide.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Metabolômica
/
Hiperinsulinismo
/
Androgênios
/
Lipoproteínas HDL
Tipo de estudo:
Etiology_studies
Limite:
Adolescent
/
Female
/
Humans
Idioma:
En
Revista:
Sci Rep
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Espanha