Reproducibility of transcranial magnetic stimulation metrics in the study of proximal upper limb muscles.
J Electromyogr Kinesiol
; 25(5): 754-64, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26111434
ABSTRACT
OBJECTIVE:
Reproducibility of transcranial magnetic stimulation (TMS) metrics is essential in accurately tracking recovery and disease. However, majority of evidence pertains to reproducibility of metrics for distal upper limb muscles. We investigate for the first time, reliability of corticospinal physiology for a large proximal muscle - the biceps brachii and relate how varying statistical analyses can influence interpretations.METHODS:
14 young right-handed healthy participants completed two sessions assessing resting motor threshold (RMT), motor evoked potentials (MEPs), motor map and intra-cortical inhibition (ICI) from the left biceps brachii. Analyses included paired t-tests, Pearson's, intra-class (ICC) and concordance correlation coefficients (CCC) and Bland-Altman plots.RESULTS:
Unlike paired t-tests, ICC, CCC and Pearson's were >0.6 indicating good reliability for RMTs, MEP intensities and locations of map; however values were <0.3 for MEP responses and ICI.CONCLUSIONS:
Corticospinal physiology, defining excitability and output in terms of intensity of the TMS device, and spatial loci are the most reliable metrics for the biceps. MEPs and variables based on MEPs are less reliable since biceps receives fewer cortico-motor-neuronal projections. Statistical tests of agreement and associations are more powerful reliability indices than inferential tests.SIGNIFICANCE:
Reliable metrics of proximal muscles when translated to a larger number of participants would serve to sensitively track and prognosticate function in neurological disorders such as stroke where proximal recovery precedes distal.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Braço
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Músculo Esquelético
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Eletromiografia
/
Estimulação Magnética Transcraniana
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Female
/
Humans
/
Male
Idioma:
En
Revista:
J Electromyogr Kinesiol
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos