Inhibition of Vascular Endothelial Growth Factor Receptor 3 Reduces Migration of Gastric Cancer Cells.
Cancer Invest
; 33(8): 398-404, 2015.
Article
em En
| MEDLINE
| ID: mdl-26115478
ABSTRACT
Angiogenesis induced by proangiogenic molecules such as vascular endothelial growth factor (VEGF) is a key process in the progression and metastasis of gastric cancer. In this study, we investigated the role of VEGF-C/VEGF receptor 3 (VEGFR3) axis in cell proliferation and migration/invasion of human gastric cancer cells (hGCCs). VEGF-C did not enhance cell proliferation but increased cell migration/invasion by approximately â¼50% in hGCCs (AGS and SNU-484). MAZ51, a VEGFR3 inhibitor, reduced the VEGF-C-induced increase in migration/invasion by â¼30% (p < 0.05). These results suggest that VEGFR3 could be a therapeutic target for reducing the metastasis of gastric cancer cells.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
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Receptor 3 de Fatores de Crescimento do Endotélio Vascular
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Indóis
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Naftalenos
Limite:
Humans
Idioma:
En
Revista:
Cancer Invest
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Coréia do Sul