A national survey of the molecular epidemiology of Clostridium difficile in Israel: the dissemination of the ribotype 027 strain with reduced susceptibility to vancomycin and metronidazole.
Diagn Microbiol Infect Dis
; 83(1): 21-4, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-26116225
ABSTRACT
Our goals were to study the molecular epidemiology and antimicrobial susceptibilities of C. difficile strains in Israel. Microbiology laboratories serving 6 general hospitals (GH) and 10 long-term care facilities (LTCF) were asked to submit all stool samples in January-February 2014 that tested positive for C. difficile. Toxigenic C. difficile isolates were recovered in 208 out of 217 samples (95.8%), of which 50 (23.6%) were from LTCFs. Ribotype 027 was the most common type overall, identified in 65 samples (31.8%), and was the predominant strain in the 3 GHs with the highest incidence of C. difficile infections. Other common strains were slpA types cr-02 (n = 45) and hr-02 (n = 18). The proportions of vancomycin and metronidazole MIC values >2mg/L were high in ribotype 027 (87.7% and 44.6%, respectively) and slpA-cr-02 strains (88.8% and 17.8%, respectively). This study demonstrates that the ribotype 027 strain has disseminated across Israel and is now the most common strain.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vancomicina
/
Clostridioides difficile
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Infecções por Clostridium
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Ribotipagem
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Farmacorresistência Bacteriana
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Metronidazol
/
Anti-Infecciosos
Tipo de estudo:
Clinical_trials
/
Incidence_studies
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Prognostic_studies
/
Screening_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Diagn Microbiol Infect Dis
Ano de publicação:
2015
Tipo de documento:
Article