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Rapid assessment of quantitative T1, T2 and T2* in lower extremity muscles in response to maximal treadmill exercise.
Varghese, Juliet; Scandling, Debbie; Joshi, Rohit; Aneja, Ashish; Craft, Jason; Raman, Subha V; Rajagopalan, Sanjay; Simonetti, Orlando P; Mihai, Georgeta.
Afiliação
  • Varghese J; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Scandling D; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.
  • Joshi R; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Aneja A; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Craft J; Department of Cardiology, MetroHealth Medical Center, Cleveland, OH, USA.
  • Raman SV; Department of Cardiology, Advocate Christ Medical Center, Oak Lawn, IL, USA.
  • Rajagopalan S; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Simonetti OP; Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Mihai G; Division of Cardiovascular Medicine, University of Maryland, Baltimore, MD, USA.
NMR Biomed ; 28(8): 998-1008, 2015 Aug.
Article em En | MEDLINE | ID: mdl-26123219
MRI provides a non-invasive diagnostic platform to quantify the physical and physiological attributes of skeletal muscle at rest and in response to exercise. MR relaxation parameters (T1, T2 and T2*) are characteristic of tissue composition and metabolic properties. With the recent advent of quantitative techniques that allow rapid acquisition of T1, T2 and T2* maps, we posited that an integrated treadmill exercise-quantitative relaxometry paradigm can rapidly characterize exercise-induced changes in skeletal muscle relaxation parameters. Accordingly, we investigated the rest/recovery kinetics of T1, T2 and T2* in response to treadmill exercise in the anterior tibialis, soleus and gastrocnemius muscles of healthy volunteers, and the relationship of these parameters to age and gender. Thirty healthy volunteers (50.3 ± 16.6 years) performed the Bruce treadmill exercise protocol to maximal exhaustion. Relaxometric maps were sequentially acquired at baseline and for approximately 44 minutes post-exercise. Our results show that T1, T2 and T2* are significantly and differentially increased immediately post-exercise among the leg muscle groups, and these values recover to near baseline within 30-44 minutes. Our results demonstrate the potential to characterize the kinetics of relaxation parameters with quantitative mapping and upright exercise, providing normative values and some clarity on the impact of age and gender.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistência Física / Envelhecimento / Imageamento por Ressonância Magnética / Exercício Físico / Músculo Esquelético / Contração Muscular Tipo de estudo: Diagnostic_studies / Guideline Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: NMR Biomed Assunto da revista: DIAGNOSTICO POR IMAGEM / MEDICINA NUCLEAR Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistência Física / Envelhecimento / Imageamento por Ressonância Magnética / Exercício Físico / Músculo Esquelético / Contração Muscular Tipo de estudo: Diagnostic_studies / Guideline Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: NMR Biomed Assunto da revista: DIAGNOSTICO POR IMAGEM / MEDICINA NUCLEAR Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos