Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake.

Funk, Kristen E; Mirbaha, Hilda; Jiang, Hong; Holtzman, David M; Diamond, Marc I

Funk, Kristen E; Mirbaha, Hilda; Jiang, Hong; Holtzman, David M; Diamond, Marc I.

Afiliação

Funk KE; From the Department of Neurology, Washington University in St. Louis, St. Louis, Missouri 63110 and.
Mirbaha H; the Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Jiang H; From the Department of Neurology, Washington University in St. Louis, St. Louis, Missouri 63110 and.
Holtzman DM; From the Department of Neurology, Washington University in St. Louis, St. Louis, Missouri 63110 and.
Diamond MI; the Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, Texas 75390 marc.diamond@utsouthwestern.edu.

J Biol Chem ; 290(35): 21652-62, 2015 Aug 28.

Article em En | MEDLINE | ID: mdl-26126828

Assuntos

Anticorpos/uso terapêutico; Microglia/metabolismo; Neurônios/metabolismo; Proteínas tau/imunologia; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/metabolismo; Doença de Alzheimer/patologia; Amiloide; Animais; Linhagem Celular; Córtex Cerebral/patologia; Proteoglicanas de Heparan Sulfato/metabolismo; Humanos; Camundongos; Estrutura Terciária de Proteína; Receptores de IgG/metabolismo; Proteínas tau/química

Palavras-chave

Tau protein (Tau); clearance; immunotherapy; microglia; neuron; tauopathy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas tau / Microglia / Anticorpos / Neurônios Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2015 Tipo de documento: Article

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