Turning Peptide Ligands into Small-Molecule Inhibitors of Protein-Protein Interactions.
Chembiochem
; 16(13): 1855-1856, 2015 Sep 07.
Article
em En
| MEDLINE
| ID: mdl-26147884
ABSTRACT
Proline makeover Truncation and extensive chemical modification of a peptide ligand yielded a biologically active, cell-permeable, peptidomimetic, small-molecule inhibitor of a protein-protein interaction. A key step in this transformation was the replacement of a tetraproline motif by two conformationally constrained diproline units that retain the molecule's PPII helix.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Chembiochem
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2015
Tipo de documento:
Article