MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients.

Lenos, Kristiaan; Goos, Jeroen A C M; Vuist, Ilona M; den Uil, Sjoerd H; Delis-van Diemen, Pien M; Belt, Eric J Th; Stockmann, Hein B A C; Bril, Herman; de Wit, Meike; Carvalho, Beatriz; Giblett, Susan; Pritchard, Catrin A; Meijer, Gerrit A; van Kooyk, Yvette; Fijneman, Remond J A; van Vliet, Sandra J

Lenos, Kristiaan; Goos, Jeroen A C M; Vuist, Ilona M; den Uil, Sjoerd H; Delis-van Diemen, Pien M; Belt, Eric J Th; Stockmann, Hein B A C; Bril, Herman; de Wit, Meike; Carvalho, Beatriz; Giblett, Susan; Pritchard, Catrin A; Meijer, Gerrit A; van Kooyk, Yvette; Fijneman, Remond J A; van Vliet, Sandra J.

Afiliação

Lenos K; Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
Goos JA; Current address: Laboratory of Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Vuist IM; Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
den Uil SH; Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
Delis-van Diemen PM; Current address: Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.
Belt EJ; Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
Stockmann HB; Department of Surgery, Spaarne Gasthuis, Haarlem, The Netherlands.
Bril H; Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
de Wit M; Current address: Netherlands Cancer Institute, Amsterdam, The Netherlands.
Carvalho B; Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands.
Giblett S; Department of Surgery, Spaarne Gasthuis, Haarlem, The Netherlands.
Pritchard CA; Department of Pathology, Spaarne Gasthuis, Haarlem, The Netherlands.
Meijer GA; Department of Medical Oncology, VU University Medical Center Amsterdam, The Netherlands.
van Kooyk Y; Current address: Netherlands Cancer Institute, Amsterdam, The Netherlands.
Fijneman RJ; Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
van Vliet SJ; Current address: Netherlands Cancer Institute, Amsterdam, The Netherlands.

Oncotarget ; 6(28): 26278-90, 2015 Sep 22.

Article em En | MEDLINE | ID: mdl-26172302

Assuntos

Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Neoplasias Colorretais/enzimologia; Neoplasias Colorretais/genética; Lectinas Tipo C/metabolismo; Mutação; Proteínas Proto-Oncogênicas B-raf/genética; Adulto; Idoso; Idoso de 80 Anos ou mais; Animais; Neoplasias Colorretais/imunologia; Neoplasias Colorretais/mortalidade; Neoplasias Colorretais/patologia; Neoplasias Colorretais/terapia; Progressão da Doença; Intervalo Livre de Doença; Feminino; Predisposição Genética para Doença; Células HT29; Humanos; Estimativa de Kaplan-Meier; Ligantes; Masculino; Camundongos Transgênicos; Pessoa de Meia-Idade; Estadiamento de Neoplasias; Fenótipo; Modelos de Riscos Proporcionais; Transdução de Sinais; Fatores de Tempo; Resultado do Tratamento; Evasão Tumoral; Regulação para Cima

Palavras-chave

BRAF; C-type lectin; MGL; colorectal cancer; glycosylation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Biomarcadores Tumorais / Lectinas Tipo C / Proteínas Proto-Oncogênicas B-raf / Mutação Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Oncotarget Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Holanda

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