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A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC.
Mohammad, Helai P; Smitheman, Kimberly N; Kamat, Chandrashekhar D; Soong, David; Federowicz, Kelly E; Van Aller, Glenn S; Schneck, Jess L; Carson, Jeffrey D; Liu, Yan; Butticello, Michael; Bonnette, William G; Gorman, Shelby A; Degenhardt, Yan; Bai, Yuchen; McCabe, Michael T; Pappalardi, Melissa B; Kasparec, Jiri; Tian, Xinrong; McNulty, Kenneth C; Rouse, Meagan; McDevitt, Patrick; Ho, Thau; Crouthamel, Michelle; Hart, Timothy K; Concha, Nestor O; McHugh, Charles F; Miller, William H; Dhanak, Dashyant; Tummino, Peter J; Carpenter, Christopher L; Johnson, Neil W; Hann, Christine L; Kruger, Ryan G.
Afiliação
  • Mohammad HP; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Smitheman KN; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Kamat CD; Oncology Department, Johns Hopkins University, Baltimore, MD 21231, USA.
  • Soong D; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Federowicz KE; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Van Aller GS; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Schneck JL; Platform Technology and Sciences, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Carson JD; Platform Technology and Sciences, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Liu Y; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Butticello M; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Bonnette WG; Platform Technology and Sciences, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Gorman SA; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Degenhardt Y; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Bai Y; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • McCabe MT; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Pappalardi MB; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Kasparec J; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Tian X; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • McNulty KC; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Rouse M; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • McDevitt P; Platform Technology and Sciences, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Ho T; Platform Technology and Sciences, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Crouthamel M; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Hart TK; Safety Assessment Department, GlaxoSmithKline, Upper Merion, PA 19406, USA.
  • Concha NO; Platform Technology and Sciences, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • McHugh CF; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Miller WH; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Dhanak D; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Tummino PJ; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Carpenter CL; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Johnson NW; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Hann CL; Oncology Department, Johns Hopkins University, Baltimore, MD 21231, USA.
  • Kruger RG; Cancer Epigenetics Department, GlaxoSmithKline, Collegeville, PA 19426, USA. Electronic address: ryan.g.kruger@gsk.com.
Cancer Cell ; 28(1): 57-69, 2015 Jul 13.
Article em En | MEDLINE | ID: mdl-26175415
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzoatos / Metilação de DNA / Ciclopropanos / Inibidores Enzimáticos / Carcinoma de Pequenas Células do Pulmão / Histona Desmetilases / Neoplasias Pulmonares / Antineoplásicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzoatos / Metilação de DNA / Ciclopropanos / Inibidores Enzimáticos / Carcinoma de Pequenas Células do Pulmão / Histona Desmetilases / Neoplasias Pulmonares / Antineoplásicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos