The prognostic significance and relationship with body composition of CCR7-positive cells in colorectal cancer.
J Surg Oncol
; 112(1): 86-92, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-26179425
ABSTRACT
BACKGROUND AND OBJECTIVES:
The host local immune response (LIR) to cancer is a determinant of cancer outcome. Regulation of this local response is largely achieved through chemokine synthesis from the tumor microenvironment such as C-Chemokine-Receptor-7 (CCR7). We examined the LIR measured as CCR7 expression, in colorectal cancers (CRC) and explored relationships with body composition (BC) and survival.METHODS:
A study of paraffin-embedded tissue specimens was carried out in 116 patients with non-metastatic CRC. CCR7 expression was determined by immunohistochemistry. Analysis of computer tomography scans was used to calculate BC parameters. Survival analyses and multivariate regression models were used.RESULTS:
High CCR7(+) cell density within the tumor stroma and at the margin was significantly associated with increased age, the presence of lymphovascular invasion, higher tumor stage, lymph node metastasis, high Klintrup-Makinen immune score, and myosteatosis. High CCR7(+) cell density in the tumor margin was significantly associated with shorter disease-free (DFS) and overall survival (OS) (P < 0.001). This was also significantly associated with shorter survival in multivariate analysis (HR = 8.87; 95%CI [2.51-31.3]; P < 0.01 for OS and HR = 4.72; 95%CI (1.24-12.9); P = 0.02 for DFS).CONCLUSIONS:
Our results suggest that a specific immune microenvironment may be associated with altered host's BC and tumor behavior, and that CCR7 may serve as a novel prognostic biomarker.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Composição Corporal
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Neoplasias Colorretais
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Biomarcadores Tumorais
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Receptores CCR7
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
J Surg Oncol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Reino Unido