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Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors.
Holzer, Philipp; Masuya, Keiichi; Furet, Pascal; Kallen, Joerg; Valat-Stachyra, Therese; Ferretti, Stéphane; Berghausen, Joerg; Bouisset-Leonard, Michèle; Buschmann, Nicole; Pissot-Soldermann, Carole; Rynn, Caroline; Ruetz, Stephan; Stutz, Stefan; Chène, Patrick; Jeay, Sébastien; Gessier, Francois.
Afiliação
  • Holzer P; Novartis Institutes for BioMedical Research , 4002 Basel, Switzerland.
  • Masuya K; Novartis Institutes for BioMedical Research , 4002 Basel, Switzerland.
  • Furet P; Novartis Institutes for BioMedical Research , 4002 Basel, Switzerland.
  • Kallen J; Novartis Institutes for BioMedical Research , 4002 Basel, Switzerland.
  • Valat-Stachyra T; Novartis Institutes for BioMedical Research , 4002 Basel, Switzerland.
  • Ferretti S; Novartis Institutes for BioMedical Research , 4002 Basel, Switzerland.
  • Berghausen J; Novartis Institutes for BioMedical Research , 4002 Basel, Switzerland.
  • Bouisset-Leonard M; Novartis Institutes for BioMedical Research , 4002 Basel, Switzerland.
  • Buschmann N; Novartis Institutes for BioMedical Research , 4002 Basel, Switzerland.
  • Pissot-Soldermann C; Novartis Institutes for BioMedical Research , 4002 Basel, Switzerland.
  • Rynn C; Novartis Institutes for BioMedical Research , 4002 Basel, Switzerland.
  • Ruetz S; Novartis Institutes for BioMedical Research , 4002 Basel, Switzerland.
  • Stutz S; Novartis Institutes for BioMedical Research , 4002 Basel, Switzerland.
  • Chène P; Novartis Institutes for BioMedical Research , 4002 Basel, Switzerland.
  • Jeay S; Novartis Institutes for BioMedical Research , 4002 Basel, Switzerland.
  • Gessier F; Novartis Institutes for BioMedical Research , 4002 Basel, Switzerland.
J Med Chem ; 58(16): 6348-58, 2015 Aug 27.
Article em En | MEDLINE | ID: mdl-26181851
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas c-mdm2 / Isoquinolinas / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Suíça
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas c-mdm2 / Isoquinolinas / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Suíça