Anti-Acetylcholinesterase Alkaloids from Annona glabra Leaf.
Nat Prod Commun
; 10(6): 891-3, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-26197510
ABSTRACT
Bioassay guided fractionation and separation of the EtOH extract of Annona glabra leaf against acetylcholinesterse led to the characterization of 15 alkaloids. Among them, (-)-actinodaphnine (2) and (-)-(6aS,7R)-7-hydroxyactinodaphnine (9) are new aporphines, although (+)-2 and (±)-2 have been found in several plants. Their structures were established by spectroscopic analysis. (-)-Anolobine (5) and (-)-roemeroline (8) showed moderate inhibitory activity against eel acetylcholinesterase with IC50 values of 22.4 and 26.3 µM, respectively.
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Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Annona
/
Alcaloides
/
Inibidores Enzimáticos
Idioma:
En
Revista:
Nat Prod Commun
Assunto da revista:
BOTANICA
/
FARMACOLOGIA
/
QUIMICA
Ano de publicação:
2015
Tipo de documento:
Article