Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43.

Walker, Adam K; Spiller, Krista J; Ge, Guanghui; Zheng, Allen; Xu, Yan; Zhou, Melissa; Tripathy, Kalyan; Kwong, Linda K; Trojanowski, John Q; Lee, Virginia M-Y

Walker, Adam K; Spiller, Krista J; Ge, Guanghui; Zheng, Allen; Xu, Yan; Zhou, Melissa; Tripathy, Kalyan; Kwong, Linda K; Trojanowski, John Q; Lee, Virginia M-Y.

Afiliação

Walker AK; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Spiller KJ; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ge G; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Zheng A; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Xu Y; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Zhou M; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Tripathy K; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Kwong LK; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Trojanowski JQ; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Lee VM; Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Acta Neuropathol ; 130(5): 643-60, 2015 Nov.

Article em En | MEDLINE | ID: mdl-26197969

Assuntos

Esclerose Lateral Amiotrófica/fisiopatologia; Citoplasma/metabolismo; Proteínas de Ligação a DNA/metabolismo; Degeneração Lobar Frontotemporal/fisiopatologia; Recuperação de Função Fisiológica/fisiologia; Esclerose Lateral Amiotrófica/patologia; Animais; Atrofia; Encéfalo/metabolismo; Encéfalo/patologia; Núcleo Celular/metabolismo; Núcleo Celular/patologia; Citoplasma/patologia; Proteínas de Ligação a DNA/genética; Modelos Animais de Doenças; Doxiciclina; Feminino; Degeneração Lobar Frontotemporal/patologia; Humanos; Masculino; Camundongos Endogâmicos C3H; Camundongos Endogâmicos C57BL; Transtornos dos Movimentos/patologia; Transtornos dos Movimentos/fisiopatologia; Músculo Esquelético/inervação; Distribuição Aleatória; Medula Espinal/metabolismo; Medula Espinal/patologia

Palavras-chave

Amyotrophic lateral sclerosis (ALS); Frontotemporal dementia (FTD); Frontotemporal lobar degeneration (FTLD); Motor neuron; Mouse model; Neurodegeneration; Spinal cord; TDP-43

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Recuperação de Função Fisiológica / Citoplasma / Proteínas de Ligação a DNA / Degeneração Lobar Frontotemporal / Esclerose Lateral Amiotrófica Tipo de estudo: Clinical_trials Limite: Animals / Female / Humans / Male Idioma: En Revista: Acta Neuropathol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

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