MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial cancer.
Tumour Biol
; 37(1): 239-51, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-26198045
ABSTRACT
MicroRNAs (miRNAs) are a class of noncoding RNAs and function as key regulators of gene expression at the post-transcriptional level. In this study, we found that miR-495 reduces cell growth, induces apoptosis and suppresses the migration of endometrial cancer by directly inhibiting FOXC1 expression. Further analysis revealed that FOXC1 promotes growth and migration and functions as an oncogene in vitro. FOXC1 overexpression reversed the cellular responses mediated by miR-495 in endometrial cancer cells. We also found that miR-495 suppresses the growth of endometrial cancer in vivo. Altogether, these results indicate that miR-495 acts as a tumour suppressor gene by targeting FOXC1 at the post-transcriptional level in endometrial cancer.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oncogenes
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Regulação Neoplásica da Expressão Gênica
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Neoplasias do Endométrio
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Proteínas Supressoras de Tumor
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MicroRNAs
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Fatores de Transcrição Forkhead
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Tumour Biol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
China