Synthesis of Thrombolytic Sol-Gel Coatings: Toward Drug-Entrapped Vascular Grafts.
J Med Chem
; 58(15): 6313-7, 2015 Aug 13.
Article
em En
| MEDLINE
| ID: mdl-26199987
ABSTRACT
As is evident from numerous investigations, drug-eluting vascular grafts and stents have not solved the main problems associated with thrombosis and due to drug release only postpone their advance for a longer period. Here we point to a potential solution of this problem by developing thrombolytic sol-gel coatings which potentially could lead to drug-entrapped vascular grafts urokinase-type plasminogen activator was entrapped within a porous alumina sol-gel film with a subsequent deposition on a polymer graft.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trombose
/
Prótese Vascular
/
Sistemas de Liberação de Medicamentos
/
Géis
Limite:
Humans
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
2015
Tipo de documento:
Article