A Small-Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidaseâ
B Activities in Models of Parkinson's Disease.
Angew Chem Int Ed Engl
; 54(37): 10821-5, 2015 Sep 07.
Article
em En
| MEDLINE
| ID: mdl-26205378
ABSTRACT
The design of the first dual-purpose activity-based probe of monoamine oxidaseâ
B (MAO-B) is reported. This probe is highly selective towards MAO-B, even at high MAO-A expression levels, and could sensitively report endogenous MAO-B activities by both inâ
situ proteome profiling and live-cell bioimaging. With a built-in imaging module as part of the probe design, the probe was able to accomplish what all previously reported MAO-B imaging probes failed to do thus far the live-cell imaging of MAO-B activities without encountering diffusion problems.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Sondas Moleculares
/
Monoaminoxidase
Limite:
Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2015
Tipo de documento:
Article