A Tutorial on Target-Mediated Drug Disposition (TMDD) Models.

Dua, P; Hawkins, E; van der Graaf, P H

Dua, P; Hawkins, E; van der Graaf, P H.

Afiliação

Dua P; Pharmatherapeutics Research Clinical Pharmacology, Pfizer Neusentis Cambridge, UK.
Hawkins E; Pharmatherapeutics Research Clinical Pharmacology, Pfizer Neusentis Cambridge, UK ; Department of Mathematics, University of Surrey Guildford, UK.
van der Graaf PH; Leiden Academic Centre for Drug Research (LACDR), Systems Pharmacology Leiden, The Netherlands.

CPT Pharmacometrics Syst Pharmacol ; 4(6): 324-37, 2015 Jun.

Article em En | MEDLINE | ID: mdl-26225261

ABSTRACT

ABSTRACT

Target-mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics.1 The aim of this Tutorial is to provide an introductory guide to the mathematical aspects of TMDD models for pharmaceutical researchers. Examples of Berkeley Madonna2 code for some models discussed in this Tutorial are provided in the Supplementary Materials.

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: CPT Pharmacometrics Syst Pharmacol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Reino Unido

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