A Tutorial on Target-Mediated Drug Disposition (TMDD) Models.
CPT Pharmacometrics Syst Pharmacol
; 4(6): 324-37, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-26225261
ABSTRACT
Target-mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics.1 The aim of this Tutorial is to provide an introductory guide to the mathematical aspects of TMDD models for pharmaceutical researchers. Examples of Berkeley Madonna2 code for some models discussed in this Tutorial are provided in the Supplementary Materials.
Texto completo:
1
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
CPT Pharmacometrics Syst Pharmacol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Reino Unido