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Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation.
Yunn, Na-Oh; Koh, Ara; Han, Seungmin; Lim, Jong Hun; Park, Sehoon; Lee, Jiyoun; Kim, Eui; Jang, Sung Key; Berggren, Per-Olof; Ryu, Sung Ho.
Afiliação
  • Yunn NO; The School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 790-784, South Korea.
  • Koh A; The Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, South Korea.
  • Han S; The Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, South Korea.
  • Lim JH; The POSTECH Aptamer Initiative Program, POSTECH Biotech Center, Pohang University of Science and Technology, Pohang 790-784, South Korea.
  • Park S; The Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, South Korea.
  • Lee J; The Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, South Korea.
  • Kim E; The Division of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology, Pohang 790-784, South Korea.
  • Jang SK; The School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 790-784, South Korea The Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, South Korea The Division of Integrative Bioscience and Biotechnology,
  • Berggren PO; The Division of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology, Pohang 790-784, South Korea The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
  • Ryu SH; The School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 790-784, South Korea The Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, South Korea The Division of Integrative Bioscience and Biotechnology,
Nucleic Acids Res ; 43(16): 7688-701, 2015 Sep 18.
Article em En | MEDLINE | ID: mdl-26245346
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor de Insulina / Transdução de Sinais / Aptâmeros de Nucleotídeos Limite: Animals / Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Coréia do Sul
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor de Insulina / Transdução de Sinais / Aptâmeros de Nucleotídeos Limite: Animals / Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Coréia do Sul