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Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus.
Andersen, Kristian G; Shapiro, B Jesse; Matranga, Christian B; Sealfon, Rachel; Lin, Aaron E; Moses, Lina M; Folarin, Onikepe A; Goba, Augustine; Odia, Ikponmwonsa; Ehiane, Philomena E; Momoh, Mambu; England, Eleina M; Winnicki, Sarah; Branco, Luis M; Gire, Stephen K; Phelan, Eric; Tariyal, Ridhi; Tewhey, Ryan; Omoniwa, Omowunmi; Fullah, Mohammed; Fonnie, Richard; Fonnie, Mbalu; Kanneh, Lansana; Jalloh, Simbirie; Gbakie, Michael; Saffa, Sidiki; Karbo, Kandeh; Gladden, Adrianne D; Qu, James; Stremlau, Matthew; Nekoui, Mahan; Finucane, Hilary K; Tabrizi, Shervin; Vitti, Joseph J; Birren, Bruce; Fitzgerald, Michael; McCowan, Caryn; Ireland, Andrea; Berlin, Aaron M; Bochicchio, James; Tazon-Vega, Barbara; Lennon, Niall J; Ryan, Elizabeth M; Bjornson, Zach; Milner, Danny A; Lukens, Amanda K; Broodie, Nisha; Rowland, Megan; Heinrich, Megan; Akdag, Marjan.
Afiliação
  • Andersen KG; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA; The Scripps Research Institute, Scripps Translational Science Institute, La Jolla, CA 92037, USA. Electronic address: andersen@s
  • Shapiro BJ; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA; Department of Biological Sciences, University of Montréal, Montréal, QC H2V 2S9, Canada.
  • Matranga CB; Broad Institute, Cambridge, MA 02142, USA.
  • Sealfon R; Broad Institute, Cambridge, MA 02142, USA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Lin AE; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA.
  • Moses LM; Tulane Health Sciences Center, Tulane University, New Orleans, LA 70118, USA.
  • Folarin OA; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria; Department of Biological Sciences, College of Natural Sciences, Redeemer's University, Redemption City, Osun State, Nigeria.
  • Goba A; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
  • Odia I; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
  • Ehiane PE; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
  • Momoh M; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone; Eastern Polytechnic College, Kenema, Eastern Province, Sierra Leone.
  • England EM; Broad Institute, Cambridge, MA 02142, USA.
  • Winnicki S; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA.
  • Branco LM; Zalgen Labs, Germantown, MD 20876, USA.
  • Gire SK; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA.
  • Phelan E; Broad Institute, Cambridge, MA 02142, USA.
  • Tariyal R; Broad Institute, Cambridge, MA 02142, USA.
  • Tewhey R; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA.
  • Omoniwa O; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
  • Fullah M; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone; Eastern Polytechnic College, Kenema, Eastern Province, Sierra Leone.
  • Fonnie R; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
  • Fonnie M; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
  • Kanneh L; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
  • Jalloh S; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
  • Gbakie M; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
  • Saffa S; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
  • Karbo K; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
  • Gladden AD; Broad Institute, Cambridge, MA 02142, USA.
  • Qu J; Broad Institute, Cambridge, MA 02142, USA.
  • Stremlau M; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA.
  • Nekoui M; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA.
  • Finucane HK; Broad Institute, Cambridge, MA 02142, USA.
  • Tabrizi S; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA.
  • Vitti JJ; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  • Birren B; Broad Institute, Cambridge, MA 02142, USA.
  • Fitzgerald M; Broad Institute, Cambridge, MA 02142, USA.
  • McCowan C; Broad Institute, Cambridge, MA 02142, USA.
  • Ireland A; Broad Institute, Cambridge, MA 02142, USA.
  • Berlin AM; Broad Institute, Cambridge, MA 02142, USA.
  • Bochicchio J; Broad Institute, Cambridge, MA 02142, USA.
  • Tazon-Vega B; Broad Institute, Cambridge, MA 02142, USA.
  • Lennon NJ; Broad Institute, Cambridge, MA 02142, USA.
  • Ryan EM; Broad Institute, Cambridge, MA 02142, USA.
  • Bjornson Z; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94304, USA.
  • Milner DA; Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA.
  • Lukens AK; Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA.
  • Broodie N; College of Medicine, Columbia University, New York, NY 10032, USA.
  • Rowland M; Zalgen Labs, Germantown, MD 20876, USA.
  • Heinrich M; Zalgen Labs, Germantown, MD 20876, USA.
  • Akdag M; Zalgen Labs, Germantown, MD 20876, USA.
Cell ; 162(4): 738-50, 2015 Aug 13.
Article em En | MEDLINE | ID: mdl-26276630
ABSTRACT
The 2013-2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause hemorrhagic fever with high case fatality rates. We generated a genomic catalog of almost 200 LASV sequences from clinical and rodent reservoir samples. We show that whereas the 2013-2015 EVD epidemic is fueled by human-to-human transmissions, LASV infections mainly result from reservoir-to-human infections. We elucidated the spread of LASV across West Africa and show that this migration was accompanied by changes in LASV genome abundance, fatality rates, codon adaptation, and translational efficiency. By investigating intrahost evolution, we found that mutations accumulate in epitopes of viral surface proteins, suggesting selection for immune escape. This catalog will serve as a foundation for the development of vaccines and diagnostics. VIDEO ABSTRACT.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Viral / Genoma Viral / Febre Lassa / Vírus Lassa Limite: Animals / Humans País/Região como assunto: Africa Idioma: En Revista: Cell Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Viral / Genoma Viral / Febre Lassa / Vírus Lassa Limite: Animals / Humans País/Região como assunto: Africa Idioma: En Revista: Cell Ano de publicação: 2015 Tipo de documento: Article