Shallow whole genome sequencing is well suited for the detection of chromosomal aberrations in human blastocysts.

Deleye, Lieselot; Dheedene, Annelies; De Coninck, Dieter; Sante, Tom; Christodoulou, Christodoulos; Heindryckx, Björn; Van den Abbeel, Etienne; De Sutter, Petra; Deforce, Dieter; Menten, Björn; Van Nieuwerburgh, Filip

Deleye, Lieselot; Dheedene, Annelies; De Coninck, Dieter; Sante, Tom; Christodoulou, Christodoulos; Heindryckx, Björn; Van den Abbeel, Etienne; De Sutter, Petra; Deforce, Dieter; Menten, Björn; Van Nieuwerburgh, Filip.

Afiliação

Deleye L; Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium.
Dheedene A; Center for Medical Genetics, Ghent University, Ghent, Belgium.
De Coninck D; Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium.
Sante T; Center for Medical Genetics, Ghent University, Ghent, Belgium.
Christodoulou C; Department for Reproductive Medicine, Ghent University Hospital, Ghent, Belgium.
Heindryckx B; Department for Reproductive Medicine, Ghent University Hospital, Ghent, Belgium.
Van den Abbeel E; Department for Reproductive Medicine, Ghent University Hospital, Ghent, Belgium.
De Sutter P; Department for Reproductive Medicine, Ghent University Hospital, Ghent, Belgium.
Deforce D; Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium.
Menten B; Center for Medical Genetics, Ghent University, Ghent, Belgium. Electronic address: Bjorn.Menten@ugent.be.
Van Nieuwerburgh F; Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium.

Fertil Steril ; 104(5): 1276-85.e1, 2015 Nov.

Article em En | MEDLINE | ID: mdl-26282994

Assuntos

Blastocisto/patologia; Transtornos Cromossômicos/genética; Cromossomos Humanos/genética; Sequenciamento de Nucleotídeos em Larga Escala; Diagnóstico Pré-Implantação/métodos; Translocação Genética; Adulto; Biópsia; Transtornos Cromossômicos/patologia; Hibridização Genômica Comparativa; Técnicas de Cultura Embrionária; Feminino; Marcadores Genéticos; Hospitais Universitários; Humanos; Masculino; Valor Preditivo dos Testes; Injeções de Esperma Intracitoplásmicas

Palavras-chave

Massive parallel sequencing; blastocyst biopsy; chromosomal rearrangements; preimplantation genetic diagnosis; whole genome amplification

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Translocação Genética / Blastocisto / Cromossomos Humanos / Diagnóstico Pré-Implantação / Transtornos Cromossômicos / Sequenciamento de Nucleotídeos em Larga Escala Tipo de estudo: Diagnostic_studies / Evaluation_studies / Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Fertil Steril Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Bélgica

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