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Mycobacterium tuberculosis pncA Polymorphisms That Do Not Confer Pyrazinamide Resistance at a Breakpoint Concentration of 100 Micrograms per Milliliter in MGIT.
Whitfield, Michael G; Warren, Robin M; Streicher, Elizabeth M; Sampson, Samantha L; Sirgel, Frik A; van Helden, Paul D; Mercante, Alexandra; Willby, Melisa; Hughes, Kelsey; Birkness, Kris; Morlock, Glenn; van Rie, Annelies; Posey, James E.
Afiliação
  • Whitfield MG; SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.
  • Warren RM; SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa rw1@sun.ac.za.
  • Streicher EM; SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.
  • Sampson SL; SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.
  • Sirgel FA; SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.
  • van Helden PD; SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.
  • Mercante A; Division of Tuberculosis Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Willby M; Division of Tuberculosis Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Hughes K; Division of Tuberculosis Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Birkness K; Division of Tuberculosis Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Morlock G; Division of Tuberculosis Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • van Rie A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Posey JE; Division of Tuberculosis Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
J Clin Microbiol ; 53(11): 3633-5, 2015 Nov.
Article em En | MEDLINE | ID: mdl-26292310
ABSTRACT
Sequencing of the Mycobacterium tuberculosis pncA gene allows for pyrazinamide susceptibility testing. We summarize data on pncA polymorphisms that do not confer resistance at a susceptibility breakpoint of 100 µg/ml pyrazinamide in MGIT within a cohort of isolates from South Africa and the U.S. Centers for Disease Control and Prevention.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazinamida / Amidoidrolases / Mycobacterium tuberculosis / Antituberculosos Limite: Humans País/Região como assunto: Africa / America do norte Idioma: En Revista: J Clin Microbiol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: África do Sul
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazinamida / Amidoidrolases / Mycobacterium tuberculosis / Antituberculosos Limite: Humans País/Região como assunto: Africa / America do norte Idioma: En Revista: J Clin Microbiol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: África do Sul