A computational tool for patient specific dosimetry and radiobiological modeling of selective internal radiation therapy with (90)Y microspheres.
Appl Radiat Isot
; 105: 123-129, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-26296058
ABSTRACT
In recent years we have witnessed tremendous progress in selective internal radiation therapy. In clinical practice, quite often, radionuclide therapy is planned using simple models based on standard activity values or activity administered per unit body weight or surface area in spite of the admission that radiation-dose methods provide more accurate dosimetric results. To address that issue, the authors developed a Matlab-based computational software, named Patient Specific Yttrium-90 Dosimetry Toolkit (PSYDT). PSYDT was designed for patient specific voxel-based dosimetric calculations and radiobiological modeling of selective internal radiation therapy with (90)Y microspheres. The developed toolkit is composed of three dimensional dose calculations for both bremsstrahlung and beta emissions. Subsequently, radiobiological modeling is performed on a per-voxel basis and cumulative dose volume histograms (DVHs) are generated. In this report we describe the functionality and visualization features of PSYDT.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Radioisótopos de Ítrio
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Planejamento da Radioterapia Assistida por Computador
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Braquiterapia
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Compostos Radiofarmacêuticos
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Modelagem Computacional Específica para o Paciente
Limite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Appl Radiat Isot
Assunto da revista:
MEDICINA NUCLEAR
/
SAUDE AMBIENTAL
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos