REDD1 Is Essential for Optimal T Cell Proliferation and Survival.
PLoS One
; 10(8): e0136323, 2015.
Article
em En
| MEDLINE
| ID: mdl-26301899
ABSTRACT
REDD1 is a highly conserved stress response protein that is upregulated following many types of cellular stress, including hypoxia, DNA damage, energy stress, ER stress, and nutrient deprivation. Recently, REDD1 was shown to be involved in dexamethasone induced autophagy in murine thymocytes. However, we know little of REDD1's function in mature T cells. Here we show for the first time that REDD1 is upregulated following T cell stimulation with PHA or CD3/CD28 beads. REDD1 knockout T cells exhibit a defect in proliferation and cell survival, although markers of activation appear normal. These findings demonstrate a previously unappreciated role for REDD1 in T cell function.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Fatores de Transcrição
/
Sobrevivência Celular
/
Proliferação de Células
Limite:
Animals
Idioma:
En
Revista:
PLoS One
Assunto da revista:
CIENCIA
/
MEDICINA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos