Development of CYP11B1 and CYP11B2 assays utilizing homogenates of adrenal glands: Utility of monkey as a surrogate for human.

Cerny, Matthew A; Csengery, Alexander; Schmenk, Jennifer; Frederick, Kosea

Cerny, Matthew A; Csengery, Alexander; Schmenk, Jennifer; Frederick, Kosea.

Afiliação

Cerny MA; Boehringer Ingelheim Pharmaceuticals, Inc., Department of Medicinal Chemistry, Drug Discovery Support (DMPK), USA. Electronic address: matthew.cerny@boehringer-ingelheim.com.
Csengery A; Boehringer Ingelheim Pharmaceuticals, Inc., Department of Medicinal Chemistry, Drug Discovery Support (DMPK), USA.
Schmenk J; Boehringer Ingelheim Pharmaceuticals, Inc., Department of Medicinal Chemistry, Drug Discovery Support (DMPK), USA.
Frederick K; Boehringer Ingelheim Pharmaceuticals, Inc., Department of Medicinal Chemistry, Drug Discovery Support (DMPK), USA.

J Steroid Biochem Mol Biol ; 154: 197-205, 2015 Nov.

Article em En | MEDLINE | ID: mdl-26303746

Assuntos

Glândulas Suprarrenais/enzimologia; Citocromo P-450 CYP11B2/metabolismo; Esteroide 11-beta-Hidroxilase/metabolismo; Animais; Citocromo P-450 CYP11B2/antagonistas & inibidores; Humanos; Cinética; Macaca fascicularis; Modelos Animais; Esteroide 11-beta-Hidroxilase/antagonistas & inibidores

Palavras-chave

Aldosterone; Aldosterone synthase; CYP11B1; CYP11B2; Cortisol; Cytochrome P450; Inhibitors

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esteroide 11-beta-Hidroxilase / Glândulas Suprarrenais / Citocromo P-450 CYP11B2 Limite: Animals / Humans Idioma: En Revista: J Steroid Biochem Mol Biol Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2015 Tipo de documento: Article

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