Surgical clipping versus endovascular coiling for elderly patients presenting with subarachnoid hemorrhage.
J Neurointerv Surg
; 8(9): 913-8, 2016 Sep.
Article
em En
| MEDLINE
| ID: mdl-26311713
ABSTRACT
BACKGROUND:
The comparative effectiveness of the two treatment options (surgical clipping and endovascular coiling) for ruptured cerebral aneurysms has not been studied in real-world practice in the USA. We investigated the association between the treatment method for ruptured cerebral aneurysms and outcomes.METHODS:
We performed a retrospective cohort study of elderly patients who underwent treatment for ruptured cerebral aneurysms from 2007 to 2012 using a 100% sample of Medicare fee-for-service claims data. An instrumental variable analysis was used to control for unmeasured confounding and to create pseudo-randomization on the treatment method. In sensitivity analysis, controlling only for measured confounding, we used propensity score conditioning and inverse probability weighting with mixed effects to account for clustering at the Hospital Referral Region (HRR) level.RESULTS:
During the study period 3210 patients underwent treatment for ruptured cerebral aneurysms and met the inclusion criteria. Of these, 1206 (37.6%) had surgical clipping and 2004 (62.4%) had endovascular coiling. Instrumental variable analysis demonstrated no difference between coiling and clipping in 1-year postoperative mortality (OR 1.04; 95% CI 0.70 to 1.54), likelihood of discharge to rehabilitation (OR 1.07; 95% CI 0.72 to 1.58), or 30-day readmission rate (OR 1.44; 95% CI 0.70 to 1.87). However, clipping was associated with 2.7â days longer length of stay (LOS) (95% CI 0.45 to 4.99). The same associations were present in propensity score adjusted and inverse probability weighted models.CONCLUSIONS:
In a cohort of Medicare patients, we did not demonstrate a difference in mortality, rate of discharge to rehabilitation, and readmissions between clipping and coiling of ruptured cerebral aneurysms. Clipping was associated with a slightly longer LOS.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hemorragia Subaracnóidea
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Instrumentos Cirúrgicos
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Aneurisma Intracraniano
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Aneurisma Roto
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Embolização Terapêutica
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Neurointerv Surg
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos