[Comparison of clinical characteristics and laboratory parameters of patients with dermatomyositis-specific autoantibodies and autoantibody-negative patients]. / Dermatomyositis-specifikus autoantitesttel rendelkezo és autoantitest-negatív betegeink klinikai jellemzoinek és laboratóriumi paramétereinek összehasonlítása.
Orv Hetil
; 156(36): 1451-9, 2015 Sep 06.
Article
em Hu
| MEDLINE
| ID: mdl-26320599
ABSTRACT
INTRODUCTION:
Myositis is an autoimmune disease characterised by proximal muscle weakness.AIM:
The aim of the authors was to determine the frequency of dermatomyositis-specific autoantibodies (anti-Mi-2, anti-transcriptional intermediary factor 1 gamma, anti-nuclear matrix protein 2, anti-small ubiquitin-like modifier activating enzyme, anti-melanoma differentiation-associated gene) in a Hungarian myositis population and to compare the clinical features with the characteristics of patients without myositis-specific antibodies.METHOD:
Antibodies were detected using immunoblot and immunoprecipitation.RESULTS:
Of the 330 patients with myositis, 48 patients showed dermatomyositis-specific antibody positivity. The frequency of antibodies in these patients was lower than those published in literature Retrospective analysis of clinical findings and medical history revealed that patients with dermatomyositis-specific autoantibody had more severe muscle weakness and severe skin lesions at the beginning of the disease.CONCLUSIONS:
Antibodies seem to be useful markers for distinct clinical subsets, for predicting the prognosis of myositis and the effectiveness of the therapy.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Debilidade Muscular
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Dermatomiosite
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
/
Humans
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Male
/
Middle aged
Idioma:
Hu
Revista:
Orv Hetil
Ano de publicação:
2015
Tipo de documento:
Article