Co-option of an Ancestral Hox-Regulated Network Underlies a Recently Evolved Morphological Novelty.
Dev Cell
; 34(5): 520-31, 2015 Sep 14.
Article
em En
| MEDLINE
| ID: mdl-26343453
ABSTRACT
The evolutionary origins of complex morphological structures such as the vertebrate eye or insect wing remain one of the greatest mysteries of biology. Recent comparative studies of gene expression imply that new structures are not built from scratch, but rather form by co-opting preexisting gene networks. A key prediction of this model is that upstream factors within the network will activate their preexisting targets (i.e., enhancers) to form novel anatomies. Here, we show how a recently derived morphological novelty present in the genitalia of D. melanogaster employs an ancestral Hox-regulated network deployed in the embryo to generate the larval posterior spiracle. We demonstrate how transcriptional enhancers and constituent transcription factor binding sites are used in both ancestral and novel contexts. These results illustrate network co-option at the level of individual connections between regulatory genes and highlight how morphological novelty may originate through the co-option of networks controlling seemingly unrelated structures.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Genes de Insetos
/
Proteínas de Homeodomínio
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Regulação da Expressão Gênica no Desenvolvimento
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Drosophila melanogaster
/
Redes Reguladoras de Genes
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Dev Cell
Assunto da revista:
EMBRIOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos