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CD4(+) T-cell survival in the GI tract requires dectin-1 during fungal infection.
Drummond, R A; Dambuza, I M; Vautier, S; Taylor, J A; Reid, D M; Bain, C C; Underhill, D M; Masopust, D; Kaplan, D H; Brown, G D.
Afiliação
  • Drummond RA; Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
  • Dambuza IM; Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
  • Vautier S; Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
  • Taylor JA; Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
  • Reid DM; Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
  • Bain CC; Institute of Infection, Immunity and Inflammation, College of Veterinary, Medical and Life Science, University of Glasgow, Scotland, UK.
  • Underhill DM; Division of Immunology, The Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Centre, Los Angeles, California, USA.
  • Masopust D; Department of Microbiology, Centre for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
  • Kaplan DH; Department of Dermatology, Centre for Immunology, University of Minnesota, Minneapolis, Minnesota, USA.
  • Brown GD; Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Mucosal Immunol ; 9(2): 492-502, 2016 Mar.
Article em En | MEDLINE | ID: mdl-26349660
Dectin-1 is an innate antifungal C-type lectin receptor necessary for protective antifungal immunity. We recently discovered that Dectin-1 is involved in controlling fungal infections of the gastrointestinal (GI) tract, but how this C-type lectin receptor mediates these activities is unknown. Here, we show that Dectin-1 is essential for driving fungal-specific CD4(+) T-cell responses in the GI tract. Loss of Dectin-1 resulted in abrogated dendritic cell responses in the mesenteric lymph nodes (mLNs) and defective T-cell co-stimulation, causing substantial increases in CD4(+) T-cell apoptosis and reductions in the cellularity of GI-associated lymphoid tissues. CD8(+) T-cell responses were unaffected by Dectin-1 deficiency. These functions of Dectin-1 have significant implications for our understanding of intestinal immunity and susceptibility to fungal infections.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Candida albicans / Candidíase / Linfócitos T CD4-Positivos / Linfócitos T CD8-Positivos / Lectinas Tipo C / Trato Gastrointestinal Limite: Animals Idioma: En Revista: Mucosal Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Candida albicans / Candidíase / Linfócitos T CD4-Positivos / Linfócitos T CD8-Positivos / Lectinas Tipo C / Trato Gastrointestinal Limite: Animals Idioma: En Revista: Mucosal Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2016 Tipo de documento: Article